Les inhibiteurs des récepteurs de l'EGF peuvent-ils accroître les effets immunomodulateurs des extraits de plantes standardisés (de lectine de gui et d'arabinoxylane) avec un résultat clinique avéré? Rapport de cas d'un patient souffrant d'adénocarcinome pulmonaire.
- Tibor Hajto*, Anna Horváth, Lilla Baranyai, Monika Kuzma et Pál Perjési, 2016
Contexte : Il est bien connu que les cellules cancéreuses sont caractérisées par la perte ou la régulation à la baisse des molécules HLA-class-I, qui ne sont ni réversibles ni réparables. Cela permet aux cellules tumorales d'échapper définitivement à la lyse des cellules T. En conséquence, une attention croissante est portée aux cellules effectrices du système immunitaire inné. Par conséquent, une attention croissante est portée sur les cellules effectrices du système immunitaire inné qui sont capables de tuer les cellules tumorales d'une manière non restreinte par le CMH. Cependant, parallèlement à la progression de la tumeur, les cellules immunitaires innées de type 1 qui inhibent la croissance tumorale sont régulées à la baisse, ce qui signifie que, parmi d'autres raisons, une dysrégulation de la signalisation EGF associée à la tumeur peut également jouer un rôle important.
Rapports de cas de patients cancéreux avec métastases hépatiques traités au moyen de préparations immunomodulaires de plantes standardisées
Abstrait : Arrière-plan : Le carcinome hépatocellulaire métastatique se manifeste souvent par une tumeur multifocale associée à
une fonction hépatique notablement réduite. Dans de nombreux cas le bénéfice résultant d’une résection hépatique ne dure pas
longtemps. Les tumeurs hépatiques disparaissent rarement complètement après la chimiothérapie et la durée des réponses est
courte. Ces dernières décennies démontrent de plus en plus qu’un trouble de l’équilibre du système inné contribue au faible
pronostic des tumeurs hépatiques.
L’activation des récepteurs de reconnaissance de motifs moléculaires provoquée par l’effet synergique des immunomodulateurs de plantes peut-elle améliorer l’efficacité du traitement oncologique ? Étude du cas d’une patiente souffrant d’un sarcome de l’utérus et de l’ovaire.
Contexte : le nombre des preuves au profit de l’hypothèse selon laquelle, tout comme pour les microbes, divers extraits de plantes contiendraient des structures similaires aux motifs moléculaires associés à des pathogènes (en anglais PAMP-like structures) et seraient capables d’activer les fonctions cellulaires de l’immunité innée de type 1 ne cesse de croître. Étant donné l’importance de ces structures dans la défense anticancéreuse et le fait que la production synthétique de structures PAMP est difficilement réalisable, les extraits de plantes au contenu standardisé de structures similaires aux PAMP peuvent signifier une promesse pour l’avenir de la thérapie du cancer.
Breast Cancer-CAM Rx
History of Past Diseases and Treatments: Right Breast Cancer – Infiltrating Ductal Carcinoma, no specific type, Grade 1 to 2. • Patient visited my clinic in August 2011 for assistance with treatment for a recently diagnosed R Breast Cancer. • December 2010, she felt lymph pain under both arms (R & L axilla) and a R breast lump became evident. • Ultrasound performed on both breasts in March 2011, where a 4.3cm mass was confirmed in the R breast at 10-11 o’clock, plus 2 possibly metastatic lymph nodes in the R axilla. • Initial FNA of 4.3cm mass at 11 o’clock, R breast showed fat necrosis and focal mild atypia. However, 2 core biopsies performed confirmed infiltrating ductal carcinoma of no specific type, Grade 1 or 2...
Breast Cancer-CAM Rx - English language
Grade 3 Breast Cancer
History of Past Diseases and Treatments: Breast Cancer Recurrence – Metastatic Invasive Ductal Carcinoma, Grade 3. • 60 year old female with a 2nd breast cancer recurrence in right axilla lymph nodes visited my clinic for complementary cancer support treatment. • Previous bouts of breast cancer (invasive ductal carcinoma) in 1991 and 2000, treated with right breast mastectomy, chemotherapy, radiotherapy and Tamoxifen...
Grade 3 Breast Cancer - English language
Bladder Cancer
History of Past Diseases and Treatments: The patient developed rheumatoid arthritis while she was studying to be a dentist at dental school. She opened her own dental clinic at the age of 29 and had a busy practice. She had severe hematuria in February 1999 and was admitted to the Urology Department at a nearby hospital for examination. Histopathological tests revealed bladder cancer...
Bladder Cancer - English language
Colon cancer
History of Past Diseases and Treatments: In December 1998, the patient found large quantities of blood in his stool, so he visited a nearby hospital to undergo a colonoscopy. As a result, he was diagnosed with colon cancer...
Colon cancer - English language
Leukaemia
Referral to hospital with a hemoglobin (Hb) value of 5.5. Bone marrow biopsy resulted in diagnosis of ALL (Pro-B-ALL) with 97% B-cells. Transfer to the intensive oncological care unit. Hemoglobin value of 4.6. Start cortisone treatment, daily EPO injections. Further deterioration of the patient’s general condition, Hb-value declines to 3.7. Initiate chemotherapy (Vincristin)...
Herpes
Radiology, cranial MRI. Clinical indications: Lethargic patient, significant migraine with aura. Assessment of the headache: visualization of left sided meningoencephalitis, temporomesial emphasis, e.g. transmigration to left maxillary sinus. Recent cortical ischemia in temporal cortex. Because of localization, herpes encephalitis must beruled out stat. An immediate referral to the emergency room was advised. No signs of distress...
Nephroblastom
Ein 4 ½ Jahre alter Patient wurde mit der Diagnose eines verdächtigen Morbus-Wilms-Syndroms in die onkologische Klinik eingeliefert. 48 Stunden zuvor bemerkte die Kindergärtnerin eine makroskopische Hämaturie (Blut im Urin), und am folgenden Tag stellte auch die Mutter eine Hämaturie bei dem Jungen fest, ohne Dysurie (schmerzhaftes Wasserlassen). Der Patient wurde daraufhin vom Urologen untersucht, und eine Ultraschalluntersuchung ergab einen verdächtigen Tumor in der linken Niere.
Nephroblastoma - English language
Nephroblastoma - Deutsche Sprache
Lymphoma
In November 1998, a 75 year old Japanese patient had surgery to remove her left breast due to primary malignant lymphoma. She then received hormone therapy in six cycles and completed it at the end of April 1999. The patient had a local recurrence, which was found by an ambulatory medical examination in June 1999. Tumor marker CA 15-3 was 85U at that time. She received chemotherapy consisting of Melphalan (4 mg for 4 days) for the first week, Methotrexate (2.5 mg for 3 days) for the second week, Procailazine (100 mg for 3 days) for the third week and Cyclophosphamide (50 mg every day) for the fourth week. In addition, she took 3 grams of Rice Bran Arabinoxylan Compound (RBAC) per day.
Ovarian Cancer
This is an interesting case of combination therapy using chemotherapy and Rice Bran Arabinoxylan Compound (RBAC) together, which resulted in a shortening of the period of complete clinical remission to only two months. It would normally take 3 to 4 months, on average, to heal a patient with cystadenoma solely with chemotherapy. A female patient was 53 years old when she was diagnosed with ovarian cancer on February 11, 1993. Her clinical symptoms included swelling of the breasts and abdominal distention. Pathological findings were high-grade serous papillary cyst adenocarcinoma in areas of undifferentiation and frequent mitosis.
Ovarian cancer - English language
Diabetes
History of Past Diseases and Treatments: In June 1993, the patient realized that he had been getting up several times during the night to urinate and felt like drinking water frequently because of a constant thirst. He went to the hospital for an examination and was diagnosed with diabetes. His blood sugar level was 320 mg/dl. In September of that year, he was hospitalized and began to receive treatment. His blood sugar level did not decrease until March 1994, when he was discharged. The recovery was delayed because he developed hepatopathy, a possible complication from diabetes. He continued treatment with insulin injections at hospital visits but the fatigue did not disappear. He also had occasional attacks of asthma and was feeling worse.
Diabetes
Clinical Record and Treatment: The patient was diagnosed with insulin-dependent diabetes mellitus in 1994. His blood sugar level was maintained between 157~160 mg/dl by taking 12 units of insulin per day. After the patient began taking 3g of Rice Bran
Arabinoxylan Compound (RBAC) per day, he was able to reduce the insulin dosage to 6 units...
Diabetes
History of Past Diseases and Treatments: In the middle of November, 1996, the patient went to a nearby hospital and presented with abnormal fatigue. His blood sugar level was 300 mg/dl and his glycohemoglobin (HbA1c) level was 9.8, so he was diagnosed with diabetes. He also had complications from the disease; he was aware that he had been eating too many sweets since the summer, but he attributed it to his fatigue. For the next month, he was put on a restricted diet and therapeutic exercise that consisted of one hour of fast walking, but these therapies were not successful. Because he was told that he had no choice but to undergo treatment with insulin, he went to K Hospital for additional treatments...
Hepatitis B
The clinical effectiveness of Rice Bran Arabinoxylan Compound (RBAC) in immunotherapy for patients with hepatitis B: Dr. Tran Thi Minh Phuong (Former Vice Dean of the Gastroenterology Department)
Abstract: Hepatitis B virus (HBV) infection is a serious global health problem with devastating consequences of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. More efficacious treatments such as mass immunization programs and safe injection techniques are essential for eliminating HBV infection and reducing global HBV-related morbidity and mortality.
Hepatitis
Clinical Record and Treatment: In early March 1996, the patient felt unusually lethargic and was diagnosed with chronic hepatitis (non-viral) and early diabetes at the H polyclinic. The patient checked in to the clinic on May 30, 1996. After rest and an intravenous injection for Major Minofargen C, his liver function temporarily stabilized and he was able to leave the clinic after a month. Thereafter, the patient experienced periodic deterioration in liver function despite continuing...
Hepatitis C
History of Past Diseases and Treatments: In 1999, the patient was found to have AST and ALT levels of more than 100 in an annual health exam. He had a complete medical checkup and was diagnosed with hepatitis C. He experienced significant fatigue and low energy. He was recommended interferon therapy, but refused for fear of adverse effects. Regular injections of Stronger Neo-Minophagen (an injectable glycyrrhiza) were the only alternative treatment he received. After six months, the level of liver function enzymes increased gradually...
Hepatitis C
History of Past Diseases and Treatments: In 1990, the patient was diagnosed with hepatitis C, but had no specific symptoms. In July 1995, a health checkup revealed an abnormality in the liver. She had a complete medical checkup at the general hospital, which revealed a 3 cm liver cancer lesion. The treatment regimen involved infusing ethanol into the affected area...
Hepatitis C
History of Past Diseases and Treatments: The patient began to feel malaise and fatigue in his lower limbs in April 1996. These symptoms persisted, so he visited a hospital in September to undergo a complete medical checkup. Both the AST and ALT levels were about 400 and he was diagnosed with viral hepatitis C. He continued rest and dietary therapy and began receiving treatment with interferon in June 1997. At this point in time, the AST and ALT levels were both between 180 and 190. In addition to interferon, the patient took Rice Bran Arabinoxylan Compound (RBAC) at 3 g daily. He remained in the hospital for the first two weeks of interferon treatment. During this period, no adverse effects were observed except a fever of 39°C or more...
Lungenkrebs
Krankengeschichte und Behandlung: Ein 67-jähriger Japaner verlor erheblich an Gewicht und litt an einem Reizhusten mit Auswurf und begab sich daraufhin im August 1996 in die Abteilung für Lungenmedizin und -chirurgie einer Klinik in Osaka, Japan. Nach einer Untersuchung wurde ihm ein Lungenkrebs mit Komplikationen und eine Lungentuberkulose diagnostiziert. Im Oktober 1996 wurde er zunächst mit Antibiotika gegen die Lungentuberkulose und dann mit Strahlentherapie gegen den Lungenkrebs behandelt. Im Dezember desselben Jahres wurde ihm zur Beseitigung eines Tumor die untere Hälfte der rechten Lunge reseziert. Im Januar 1997 wurde der Patient aus der Klinik entlassen. Fünf Monate später verspürte er Schmerzen rechts im Brustkorb, woraufhin man bei einer Untersuchung mehrere Knochenmetastasen fand...
Lungenkrebs - Deutsche Sprache
Lung cancer
Clinical Record and Treatment: A male Japanese patient, aged 67, lost substantial weight and suffered from a hacking cough with sputum, which brought him to the Department of Respiratory Medicine and Surgery at a hospital in Osaka, Japan in August 1996. At the examination he was diagnosed with lung cancer complications and pulmonary tuberculosis. In October 1996, he was first treated with antibiotics for pulmonary tuberculosis and then with irradiation therapy for lung cancer...
Lung cancer - English language
Lung cancer
Medical evaluation: strong suspicion of a bronchial carcinoma located centrally in the left main bronchus, space occupying size of 3.5 x 3 cm...
Lung cancer - English language
Uterus and ovary sarcoma
Can a synergistic activation of pattern recognition receptors by plant immunomodulators enhance the effect of oncologic therapy? Case Report of a patient with uterus and ovary sarcoma
Tibor Hajto, Lilla Baranyai, Angelika Kirsch, Monika Kuzma and Pal Perjési
Rapports de cas de patients cancéreux
Rapports de cas de patients cancéreux avec métastases hépatiques traités au moyen de préparations immunomodulaires de plantes standardisées. Tibor Hajto et Angelika Kirsch
Le carcinome hépatocellulaire métastatique se manifeste souvent par une tumeur multifocale associée à une fonction hépatique notablement réduite. Dans de nombreux cas le bénéfice résultant d’une résection hépatique ne dure pas longtemps. Les tumeurs hépatiques disparaissent rarement complètement après la chimiothérapie et la durée des réponses est courte. Ces dernières décennies démontrent de plus en plus qu’un trouble de l’équilibre du système inné contribue au faible pronostic des tumeurs hépatiques...
Rapports de cas de patients cancéreux
Rapports de cas de patients cancéreux avec métastases hépatiques traités au moyen de préparations immunomodulaires de plantes standardisées. Tibor Hajto et Angelika Kirsch
Le carcinome hépatocellulaire métastatique se manifeste souvent par une tumeur multifocale associée à une fonction hépatique notablement réduite. Dans de nombreux cas le bénéfice résultant d’une résection hépatique ne dure pas longtemps. Les tumeurs hépatiques disparaissent rarement complètement après la chimiothérapie et la durée des réponses est courte. Ces dernières décennies démontrent de plus en plus qu’un trouble de l’équilibre du système inné contribue au faible pronostic des tumeurs hépatiques...